We are currently recruiting participants for the research studies listed below. Please contact the respective study coordinator if you are interested in participating or would like more information.
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Personalizing Osteoporosis Care:
Atypical Femur Fracture (AFF) Clinical and Genetic Risk Factors Study (2018)
Fractures from osteoporosis are more common than heart attack, stroke and breast cancer combined
The current approach to preventing osteoporosis related fractures is to provide very different types of people similar types of bone medications in standard dosage, regardless of sex, age, or race, weight or health status. But not all patients experience the same benefits or side effects from treatment. We want to understand why and how treatment can be more personalized in the future.
Medical researchers from across Canada are looking for volunteers to help them understand how to personalize osteoporosis care.
What is the Personalizing Osteoporosis Care: Atypical Femur Fracture (AFF) Clinical and Genetic Risk Factors Study?
This national study is examining the relationship between the use of bone medications and genetic makeup for the risk of developing an AFF.
Specifically we are looking at whether clinical or genetic factors influence the benefits or risks of bone medications, and possible side effects such as Atypical Femur Fractures (AFFs), a serious type of fracture that is not well understood.
Who should participate in this study?
We encourage you to participate if you are:
- a woman over 18 years of age
- have taken bone medications such as
- Risedronate (Actonel)
- Alendronate (Fosamax, Fosavance)
- Etidronate (Didronel, Didrocal)
- Zolendronate (Aclasta, Reclast)
- Pamidronate (Aredia)
- Prolia (denosumab)
- Have or have not had an atypical femur fracture
What can I expect as a participant?
As a participant in this study, we would ask you to attend one of our collaborating centres in your area for a one-time visit, and provide the following:
- Answer questions about your medical/family health history,
- Blood samples for genetic testing, bone health blood tests, and other bone biomarkers,
- Fingernail samples to examine protein structure,
- X-rays of your femurs, either to confirm your AFF or to make sure you don’t have one,
- Bone Mineral Density scan to assess the health of your bones.
Why should you participate?
Osteoporosis can strike at any age and affect both women and men. 1 on 3 women and 1 in 5 men will suffer from an osteoporotic fracture during their lifetime.
The current approach to preventing osteoporosis fractures is a “one size fits all” approach. Drug therapies given to patients come in one standard dose, regardless of sex, age, race, and drug metabolism.
We aim to change this by understanding how people respond to medications based on medical history and genetics. With the results of this study, we can identify the best treatment with minimal side effects for each person.
Personalizing osteoporosis treatment is the next step in bone health!
Funding for this study is granted by the Canadian Institute for Health Research
Dr. Angela M. Cheung MD, PhD
Canada Research Chair in Musculoskeletal & Postmenopausal Health
University Health Network (UHN)
Toronto General Hospital
North Building, 7th Floor, Room 7N-700
585 University Avenue
Toronto, ON M5G 2N2
For more information, or to participate, please contact your closest participating centre in Ontario (with more opening soon):
University Health Network, Toronto, ON
Phone: 416-340-4800 x5703 Sam
Phone: 416-340-4800 x8049 余憶眉
The PEN-AFF Study
This study will explore better ways to measure the chance of broken bones (fractures). For more information please click here.
You can participate if you:
- Are a woman
- Do not have diabetes
- Do not have kidney disease
- Do not have inflammatory disease
- Taken 3 or more years of osteoporosis medications
Call: Dr. Evelyn Wong 416-340-4840
Exercise study for men with prostate cancer
This study tests the effectiveness of 2 types of exercise program delivery methods for prostate cancer patients who are taking androgen deprivation therapy (ADT). By doing this research, we hope to better understand the benefits that different programs offer to patients and to find out which program types are most effective and practical. Ultimately, this research will assist in developing and delivering patient programs that focus on managing side-effect of androgen deprivation therapy. This study is currently recruiting study participants. For more information please visit here
Henriette Breunis| firstname.lastname@example.org
Sara Durbano| email@example.com
The Ankle Fractures and Bone-Muscle Quality Study
This 250-participant study will examine how various functional, imaging and questionnaire-type tools quantifying leg muscle, bone quality and physical function will help with future ankle fracture risk assessment and prevention.
You can participate if you:
- Are a woman or man 50 years or older
- Have never fractured an ankle
- Do not have any implants at the ankle
- Have no muscle or Achilles tendon disorders
Ankle Fracture Study Hotline: (416) 340-4800 ext 6276